Nutrition, Inflammation and Metabolism: Integrated Strategies for Prevention and Treatment of Diseases (NUIM)
Group leaders
Objectives
Objectives of the Translational Research Program
Description of the main objectives of the Program.
General scientific objectives
- Advance mechanistic understanding of how nutrition modulates biological processes involved in health and disease, integrating molecular, metabolic, microbial, and inflammatory pathways, and accounting for the lifestyle factors (sleep, physical activity, circadian rhythm, stress) that modify these relationships.
- Evaluate the effects of nutritional strategies across the health-disease continuum, from prevention to clinical management, using experimental, clinical, and real-world evidence approaches.
- Promote personalized nutrition by integrating nutritional, metabolic, microbial, and genetic biomarkers to tailor dietary interventions and improve health outcomes.
Specific Scientific Objectives
OBJ 1. Investigate the relationship between diet, gut microbiota, and systemic inflammation, identifying causal mechanisms and potential therapeutic targets relevant to metabolic, inflammatory, and chronic diseases.
OBJ 2. Assess the impact of diverse nutritional interventions (dietary patterns, functional foods, supplementation, and dietary timing) on biological markers, clinical outcomes, and disease risk.
OBJ 3. Identify and validate nutritional and genetic biomarkers to support risk stratification, early detection, and personalized dietary recommendations.
OBJ 4. Characterize how lifestyle factors, particularly sleep, circadian patterns, physical activity, and stress, modify the impact of nutrition on inflammation, microbiome dynamics, and metabolic health, recognizing that nutritional effects cannot be fully understood in isolation from the behavioral and physiological context in which food is consumed and metabolized.
OBJ 5. Facilitate translational pathways from basic discoveries to clinical studies and population-based.
